The smallpox apocalypse is unparalleled in history—it killed an estimated 300 million to 500 million people in the 20th century alone. It was declared eradicated in 1980 following a global immunization campaign led by the World Health Organization. The earliest written description of a disease that clearly resembles smallpox appeared in … On December 9, 1979, a commission of scientists declare that smallpox has been eradicated.

Smallpox is thought to date back to the Egyptian Empire around the 3 rd century BCE (Before Common Era), based on a smallpox-like rash found on three mummies.

Smallpox is an acute contagious disease caused by the variola virus, a member of the orthopoxvirus family. Smallpox was eradicated through the effective Intensified Smallpox Eradication Programme, initiated by the World Health Organization. The final large population containing smallpox was Dhaka, Bangladesh. The last known natural case was in Somalia in 1977. It was one of the world's most devastating diseases known to humanity. By a process of relentless and exhaustive vaccination.

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